Studies on scale-up of tubular film extrusion. II. The scale-up rule.

Production Scale Up of Nanofibers: A Review

A Scale-up Design Procedure for Rotating Biological Contactors

A scale-up design procedure, based on a new physical mass transfer (PMT) model, whichdescribes the performance, for aerobic rotating biological contactors (RBC’s) is developed. This scale-up procedure can be used to determine the disc surface area needed to prevent an oxygen limitation or to obtain a specific degree of treatment. In contrast to the empirical, and most previous RBC performance m...

Ignitor Scale-up Studies (dignitor)* Mnd

An analysis of a scaled-up version of IGNITOR (to a major radius of 2.16 m) is discussed. The design, referred to as DIGNITOR, is a direct extrapolation of IGNITOR. The consequences from the increased size are discussed (mainly due to decreased temperature excursions). A summary of comprehensive calculations of the stresses (documented in an accompanying paper) are presented. The case of a dive...

Scale-up studies on high shear wet granulation process from mini-scale to commercial scale.

A newly developed mini-scale high shear granulator was used for scale-up study of wet granulation process from 0.2 to 200 L scales. Under various operation conditions and granulation bowl sizes, powder mixture composed of anhydrous caffeine, D-mannitol, dibasic calcium phosphate, pregelatinized starch and corn starch was granulated by adding water. The granules were tabletted, and disintegratio...

Industrial scale-up of countercurrent chromatography: predictive scale-up.

This study describes how scale-up in countercurrent chromatography (CCC) can be simply predicted on a process scale CCC device by running a preliminary analytical-sized sample and having knowledge of the stationary-phase retention at scale-up conditions. Results have shown that simple experimentation can lead within a day to a process with the capability of several kilograms per day (tons per y...